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Trends Biochem Sci. 1995 Jul;20(7):267-71.

Protein phosphorylation and regulation of carbon metabolism in gram-negative versus gram-positive bacteria.

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Department of Biology, University of California at San Diego, La Jolla 92093-0116, USA.


Bacteria impose regulatory mechanisms on metabolic processes to ensure that the needs of the cell are met but not exceeded. Here, we discuss the basic features of a mechanism by which carbohydrate catabolism in Gram-positive bacteria is regulated. Although the physiological consequences of this regulation are the same as in Gram-negative bacteria, the mechanism is entirely different. These regulatory processes evidently evolved late, after the divergence of Gram-negative bacteria, even though the targets of regulation are universal.

[Indexed for MEDLINE]

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