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Curr Opin Cell Biol. 1995 Jun;7(3):414-20.

Eukaryotic DNA replication.

Author information

1
Department of Biochemistry, University of California, San Francisco 94143-0448, USA.

Abstract

Recent discoveries suggest that the initiation of eukaryotic DNA replication involves at least two steps--one occurring near the completion of mitosis and the other at the onset of S phase--that bring about the ordered assembly of initiator proteins at the origin. The identification and characterization of components involved in promoting or antagonizing each of these steps has provided a preliminary understanding of how replication initiation is regulated so precisely during the cell cycle.

PMID:
7662373
DOI:
10.1016/0955-0674(95)80098-0
[Indexed for MEDLINE]

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