Format

Send to

Choose Destination
Curr Opin Cell Biol. 1995 Jun;7(3):399-405.

Transgenes and gene suppression: telling us something new?

Author information

1
Department of Microbiology, Oregon State University, Corvallis 97331-3804, USA.

Abstract

Transgenes provide unique opportunities to assess the relationship between genotype and phenotype in an organism. In most cases, introduction and subsequent expression of a transgene will increase (with a sense RNA) or decrease (with an antisense RNA) the steady-state level of a specific gene product. However, a number of surprising observations have been made in the course of many transgenic studies. We develop a hypothesis that suggests that many examples of endogenous gene suppression by either antisense or sense transcripts are mediated by the same cellular mechanism.

PMID:
7662371
DOI:
10.1016/0955-0674(95)80096-4
[Indexed for MEDLINE]

Supplemental Content

Full text links

Icon for Elsevier Science
Loading ...
Support Center