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Curr Opin Cell Biol. 1995 Jun;7(3):362-70.

Higher-order nucleoprotein complexes in transcription: analogies with site-specific recombination.

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  • 1Howard Hughes Medical Institute, Department of Microbiology, University of California, San Francisco 94143-0414, USA.


Regulation of transcription involves the assembly of multiprotein complexes at enhancers and promoters. Interactions between adjacent and non-adjacent DNA-binding proteins can augment the specificity and stability of multi-component nucleoprotein complexes. Recently, several proteins have been identified that can function as 'architectural' elements in the assembly of higher-order nucleoprotein structures reminiscent of those involved in site-specific recombination in prokaryotes.

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