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Curr Opin Cell Biol. 1995 Jun;7(3):337-43.

Nuclear changes in apoptosis.

Author information

1
Department of Cell Biology and Anatomy, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.

Abstract

Specific proteinases of the Ced-3/interleukin-1 beta converting enzyme family trigger a multi-enzyme cascade that drives apoptotic events. Studies with newly developed cell-free systems have begun to identify the substrates of these and other proteinases in apoptosis. Studies with intact cells have revealed that cleavage of the genome into domain-sized fragments precedes the activation of a second nuclease that fragments the DNA into nucleosome-sized pieces.

PMID:
7662363
DOI:
10.1016/0955-0674(95)80088-3
[Indexed for MEDLINE]

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