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Curr Opin Cell Biol. 1995 Jun;7(3):329-36.

The SMC family: from chromosome condensation to dosage compensation.

Author information

1
Department of Pharmacology, University of California, San Francisco 94143-0450, USA.

Abstract

Recent genetic analyses in yeasts and biochemical studies in vertebrate cells have led to the discovery of a family of putative ATPases that play a fundamental role in chromosome condensation and segregation in mitosis. One of the members was also found to be involved in dosage compensation in Caenorhabditis elegans, providing a new link between global regulation of gene expression and chromosome structure. This unique family of proteins may control higher-order chromosome dynamics by regulated self-assembly or mechanochemical activity.

PMID:
7662362
DOI:
10.1016/0955-0674(95)80087-5
[Indexed for MEDLINE]

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