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Toxicon. 1995 May;33(5):603-13.

Characterization of a potassium channel toxin from the Caribbean Sea anemone Stichodactyla helianthus.

Author information

1
Facultad de Biología, Universidad de La Habana, Cuba.

Abstract

A peptide toxin, ShK, that blocks voltage-dependent potassium channels was isolated from the whole body extract of the Caribbean sea anemone Stichodactyla helianthus. It competes with dendrotoxin I and alpha-dendrotoxin for binding to synaptosomal membranes of rat brain, facilities acetylcholine release at an avian neuromuscular junction and suppresses K+ currents in rat dorsal root ganglion neurones in culture. Its amino acid sequence is R1SCIDTIPKS10RCTAFQCKHS20MKYRLSFCRK30TCGTC35. There is no homology with other K+ channel-blocking peptides, except for BgK from the sea anemone Bunodosoma granulifera. ShK and BgK appear to be in a different structural class from other toxins affecting K+ channels.

PMID:
7660365
DOI:
10.1016/0041-0101(95)00013-c
[Indexed for MEDLINE]

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