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FEBS Lett. 1995 Aug 21;370(3):163-9.

Solution structure of omega-conotoxin MVIIA using 2D NMR spectroscopy.

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1
Department of Pharmaceutical Chemistry, University of California, San Francisco 94143, USA.

Abstract

The solution structure of omega-conotoxin MVIIA (SNX-111), a peptide toxin from the fish hunting cone snail Conus magus and a high-affinity blocker of N-type calcium channels, was determined by 2D NMR spectroscopy. The backbones of the best 44 structures match with an average pairwise RMSD of 0.59 angstroms. The structures contain a short segment of triple-stranded beta-sheet involving residues 6-8, 20-21, and 24-25. The structure of this toxin is very similar to that of omega-conotoxin GVIA with which is has only 40% sequence homology, but very similar calcium channel binding affinity and selectivity.

PMID:
7656969
[Indexed for MEDLINE]
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