Format

Send to

Choose Destination
See comment in PubMed Commons below
J Epidemiol Community Health. 1995 Aug;49(4):437-9.

Apparent association between benzene and childhood leukaemia: methodological doubts concerning a report by Knox.

Author information

1
Department of Statistics, University of Oxford.

Abstract

A recent study by Knox concludes that cases and "clusters" of two or more cases of childhood leukaemia and non-Hodgkin's lymphoma occur closer to many kinds of industrial installation than to supposedly comparable control locations. It is argued that these findings could be largely or entirely artefactual, the apparent differences arising out of the inappropriateness of the control data. Knox used randomly selected postcode units as controls, a procedure that leads to the comparison of individuals located in areas with typically quite different population densities from those for the cases. The resulting potential for bias is explored and the arguments are exemplified by analysing household data based on postcodes.

PMID:
7650470
PMCID:
PMC1060135
[Indexed for MEDLINE]
Free PMC Article
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for HighWire Icon for PubMed Central
    Loading ...
    Support Center