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Curr Eye Res. 1995 May;14(5):399-404.

Murine model of anterior and posterior ocular melanoma.

Author information

1
Department of Ophthalmology, Emory University School of Medicine, Atlanta, GA 30322, USA.

Abstract

Iris melanomas are less likely to metastasize than ciliary body or choroidal melanomas. In order to study this difference in metastatic rate, we developed a murine model of anterior chamber (AC) and posterior compartment (PC) melanoma. Eighteen C57BL6 mice were inoculated in the AC (n = 6) or PC (n = 12) with B16F10 melanoma cells and eleven mice were inoculated in the AC (n = 3) or PC (n = 8) with Queens melanoma cells. The animals were sacrificed at 12 to 14 days post inoculation and histologically examined. Results were that 8 of 9 AC tumors and 10 of 20 PC tumors grew. One PC tumor metastasized to the lungs. This model may be used to study anterior versus posterior ocular melanoma differences.

PMID:
7648866
DOI:
10.3109/02713689508999938
[Indexed for MEDLINE]

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