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J Cardiovasc Electrophysiol. 1995 Apr;6(4):279-82.

Early afterdepolarization abolished by potassium channel opener in a patient with idiopathic long QT syndrome.

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Department of Cardiovascular Medicine, Okayama University, Japan.


We describe a 17-year-old boy with idiopathic long QT syndrome and repeated syncopal episodes. Early afterdepolarization (EAD) in the monophasic action potential (MAP) was demonstrated in the posterior septum of the left ventricle. Injection of the potassium channel opener nicorandil decreased EAD and shortened MAP duration. The syncopal episodes due to ventricular fibrillation disappeared after administration of the potassium channel opener.

[Indexed for MEDLINE]

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