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Int J Obes Relat Metab Disord. 1995 May;19(5):293-8.

Total but not bioavailable testosterone is a predictor of central adiposity in postmenopausal women.

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1
Department of Family and Preventive Medicine, University of California, San Diego, La Jolla, C 92093-0628, USA.

Abstract

OBJECTIVE:

In pre and postmenopausal women low levels of sex hormone binding globulin (SHBG) have been shown to be associated with a large waist-hip ratio (WHR), a measure of visceral adiposity. Previous studies of WHR and testosterone, however, have been inconclusive.

DESIGN:

We examined the prospective association between endogenous total and bioavailable testosterone and SHBG levels at baseline with WHR measured 12-15 years later in a community-based cohort of older women.

SETTING:

Rancho Bernardo, California.

SUBJECTS:

334 postmenopausal women.

MAIN OUTCOME MEASURES:

Endogenous total and bioavailable testosterone and SHBG levels and WHR.

RESULTS:

Only age-adjusted SHBG levels and the testosterone/SHBG ratio were associated with BMI. Age-adjusted SHBG levels and total testosterone decreased with increasing WHR. Neither measured nor estimated (testosterone/SHBG ratio) bioavailable testosterone was associated with WHR before or after adjustment for age, BMI, and cigarette smoking.

CONCLUSION:

These prospective data confirm the reported cross-sectional association between SHBG and WHR, but show no association with measured bioavailable testosterone or the testosterone/SHBG ratio. These findings do not support the premise that androgens cause visceral adiposity in postmenopausal women.

PMID:
7647819
[Indexed for MEDLINE]
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