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Nat Genet. 1995 May;10(1):56-60.

Localization of a gene for partial epilepsy to chromosome 10q.

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1
G. H. Sergievsky Center, School of Public Health, Columbia University, New York, New York 10032, USA.

Abstract

There is strong evidence for a genetic contribution to epilepsy, but it is commonly assumed that this genetic contribution is limited to 'generalized' epilepsies, and that most forms of 'partial' epilepsy are nongenetic. In a linkage analysis of a single family containing 11 affected individuals, we obtained strong evidence for localization of a gene for partial epilepsy. This susceptibility gene maps to chromosome 10q, with a maximum two-point lod score for D10S192 of 3.99 at theta = 0.0. All affected individuals share a single haplotype for seven tightly linked contiguous markers; the maximum lod score for this haplotype is 4.83 at theta = 0.0. Key recombinants place the susceptibility locus within a 10 centimorgan interval.

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PMID:
7647791
PMCID:
PMC2823475
DOI:
10.1038/ng0595-56
[Indexed for MEDLINE]
Free PMC Article
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