Format

Send to

Choose Destination
Semin Cancer Biol. 1995 Apr;6(2):91-8.

Transcriptional control by the retinoblastoma protein.

Author information

1
Wellcome/CRC Institute, Cambridge, UK.

Abstract

The retinoblastoma gene product is an abundant nuclear protein whose 'pocket domain' mediates numerous protein-protein interactions. A substantial proportion of the RB-interacting proteins are transcription factors suggesting that RB plays a fundamental role in the regulation of transcription. Via these interactions, RB can influence both the progression through the cell cycle and the expression of lineage specific products. In this review I discuss some of the likely mechanisms by which RB regulates cell proliferation and differentiation.

PMID:
7647311
DOI:
10.1006/scbi.1995.0012
[Indexed for MEDLINE]

Supplemental Content

Full text links

Icon for Elsevier Science
Loading ...
Support Center