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Bioessays. 1995 Jul;17(7):587-91.

Nuclear organization: uniting replication foci, chromatin domains and chromosome structure.

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1
CRC Nuclear Structure and Function Research Group, Sir William Dunn School of Pathology, University of Oxford, UK.

Abstract

In higher eukaryotes, 'replication factories' coordinate DNA synthesis within local clusters of chromatin domains. Recent experiments (1, 2) have confirmed the complexity of these clusters and established that the organization of sites labelled during S phase persists throughout the cell cycle. This implies that domain clusters are critical elements of an hierarchy that is fundamental to both nuclear and chromosome structure.

PMID:
7646480
DOI:
10.1002/bies.950170704
[Indexed for MEDLINE]
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