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Anticancer Res. 1995 May-Jun;15(3):811-4.

RS-33295-198: a novel, potent modulator of P-glycoprotein-mediated multidrug resistance.

Author information

1
Institute of Biochemistry and Cell Biology, Palo Alto, CA, USA.

Abstract

A novel multidrug resistance modulator, RS-33295-198, circumvented drug resistance in human, mouse, and Chinese hamster cell lines overexpressing P-glycoprotein. It enhanced the antiproliferative activity of doxorubicin, vincristine, etoposide, and paclitaxel and increased doxorubicin retention in multidrug-resistant hamster CHRC5 cells. RS-33295-198 modulated doxorubicin resistance in a murine P388/ADR leukemia model when administered ip via continuous minipump delivery, ip by bolus injection, and orally; it also improved the efficacy of vincristine toward P388/VCR leukemia when given ip or po. RS-33295-198 showed weak activity in enhancing doxorubicin efficacy against a multidrug-resistant human sarcoma xenograft.

PMID:
7645963
[Indexed for MEDLINE]

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