Heterogeneity of GABAA-receptors: cell-specific expression, pharmacology, and regulation

H Mohler; F Knoflach; J Paysan; K Motejlek; D Benke; B Lüscher; J M Fritschy

doi:10.1007/BF01694546

Heterogeneity of GABAA-receptors: cell-specific expression, pharmacology, and regulation

Neurochem Res. 1995 May;20(5):631-6. doi: 10.1007/BF01694546.

Authors

H Mohler¹, F Knoflach, J Paysan, K Motejlek, D Benke, B Lüscher, J M Fritschy

Affiliation

¹ Institute of Pharmacology, University, Zürich, Switzerland.

PMID: 7643969
DOI: 10.1007/BF01694546

Abstract

Vigilance, anxiety, memory, epileptogenic activity and muscle tension can be regulated by a modulation of GABAA-receptor function. A multitude of different GABAA-receptors exist in the brain due to the combinational assembly of various subunits encoded by at least 15 genes. The clarification of the physiological and pharmacological significance of GABAA-receptor subtypes, in combination with their cellular localization, will make it possible to identify the neuronal circuits regulating the respective CNS states and to provide strategies for the development of subtype-specific drugs for selective therapies.

Publication types

Research Support, Non-U.S. Gov't
Review

MeSH terms

Animals
Brain / cytology
Brain / metabolism
Gene Expression Regulation / physiology
Immunohistochemistry
Neurons / chemistry
Receptors, GABA-A / analysis*
Receptors, GABA-A / chemistry
Receptors, GABA-A / drug effects

Substances

Receptors, GABA-A