Format

Send to

Choose Destination
See comment in PubMed Commons below
Neurochem Res. 1995 May;20(5):631-6.

Heterogeneity of GABAA-receptors: cell-specific expression, pharmacology, and regulation.

Author information

1
Institute of Pharmacology, University, Zürich, Switzerland.

Abstract

Vigilance, anxiety, memory, epileptogenic activity and muscle tension can be regulated by a modulation of GABAA-receptor function. A multitude of different GABAA-receptors exist in the brain due to the combinational assembly of various subunits encoded by at least 15 genes. The clarification of the physiological and pharmacological significance of GABAA-receptor subtypes, in combination with their cellular localization, will make it possible to identify the neuronal circuits regulating the respective CNS states and to provide strategies for the development of subtype-specific drugs for selective therapies.

PMID:
7643969
[Indexed for MEDLINE]
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Loading ...
    Support Center