Send to

Choose Destination
See comment in PubMed Commons below
FEBS Lett. 1995 Aug 1;369(1):113-7.

The structure of the NF-kappa B p50:DNA-complex: a starting point for analyzing the Rel family.

Author information

  • 1Howard Hughes Medical Institute, Cambridge, MA 02138, USA.


The Rel family comprises a group of structurally related, eukaryotic transcription factors. The similarity extends over about 300 amino acid residues, the Rel homology region, which is responsible for DNA binding and dimerization. Two independently determined structures of homodimeric NF-kappa B p50 bound to DNA show the Rel homology regions and the DNA target sites. The protein consists of two beta-barrel domains connected by a short linker. Five loops per monomer contact the DNA. Different half-site spacings in the two structures lead to different relative orientations of N- and C-terminal domains.

[PubMed - indexed for MEDLINE]
Free full text
PubMed Commons home

PubMed Commons

How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Wiley
    Loading ...
    Support Center