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Cell Biol Int. 1995 May;19(5):373-88.

Transforming growth factor alpha.

Author information

1
Academic Surgical Unit, London Hospital Medical College, UK.

Abstract

Transforming growth factor alpha (TGF alpha) is a close relative of epidermal growth factor (EGF), the first polypeptide mitogen discovered in 1962 (Cohen, 1962). TGF alpha, like EGF, exerts its effect on cells through binding to the EGF-Receptor (EGF-R). Here we review the molecular and cell biology of TGF alpha before proceeding to describe our own work on signaling molecules induced in response to activation of the EGF-R.

PMID:
7640654
DOI:
10.1006/cbir.1995.1083
[Indexed for MEDLINE]

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