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Arch Ophthalmol. 1995 Aug;113(8):1041-4.

Anterior ischemic optic neuropathy secondary to interferon alfa.

Author information

1
Midwest Eye Institute/Methodist Hospital of Indiana, Indianapolis, USA.

Abstract

OBJECTIVE:

To report the occurrence of anterior ischemic optic neuropathy as a complication of treatment with interferon alfa and to consider the possible underlying mechanisms for this association.

DESIGN:

Description of the clinical findings in two patients with this condition.

SETTING:

A neuro-ophthalmology referral center.

PATIENTS:

Two patients, ages 40 and 51 years, undergoing treatment with interferon alfa for malignant neoplasms experienced sudden bilateral, sequential visual loss with disc-related field defects and segmental optic disc edema.

INTERVENTIONS:

Treatment with aspirin and prednisone in one patient.

MAIN OUTCOME MEASURES:

Visual acuity, color vision, Goldmann perimetry testing, and fundus photography.

RESULTS:

Visual loss was mild and generally nonprogressive. The interval between initiating treatment with interferon alfa and onset of anterior ischemic optic neuropathy was similar to that of interferon-associated vascular retinopathy.

CONCLUSION:

Anterior ischemic optic neuropathy may complicate treatment with interferon alfa. The underlying pathogenesis is probably multifactorial.

[Indexed for MEDLINE]

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