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Am J Cardiol. 1995 Aug 15;76(5):396-8.

Impact of a thrombolysis research trial on time to treatment for acute myocardial infarction in the emergency department.

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Cardiology Division, Hennepin County Medical Center, Minneapolis, Minnesota 55415, USA.


Because time to treatment in AMI is a critical factor in long-term outcome, it is important that complex trials designed to improve reperfusion therapy do not delay the time to treatment. Participation in the TIMI 5 trial did not significantly prolong our door-to-needle time. These results indicate that, if done carefully, complex, labor-intensive studies can be performed within a reasonable time limit. Care should be taken to design protocols incorporating easy drug preparation, informed consent by the ED, and efficiency of trial initiation.

[Indexed for MEDLINE]

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