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Vaccine. 1995 Apr;13(5):443-7.

Quantification of hepatitis B vaccine-induced antibodies as a predictor of anti-HBs persistence.

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Institut für Laboratoriumsmedizin, St Markus-Krankenhaus, Frankfurt am Main, Germany.


Hepatitis B vaccine-induced antibodies (anti-HBs) were quantified in 35 subjects (study group) and in an additional 24-59 subjects (controls) during a period of 82 months after vaccination against hepatitis B and the values used as a basis to develop a logarithmic formula to describe the post-booster antibody kinetics. The actual anti-HBs titres are shown to be proportional to the peak titre one month post-booster but inversely proportional to the number of months between the time of booster and of retesting. Using this model and an anti-HBs quantification more than a month post-booster, the individual persistence of vaccine-induced anti-HBs antibodies can be calculated.

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