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J Urol. 1995 Sep;154(3):1035-40.

Intermittent shedding of human immunodeficiency virus in semen: implications for sexual transmission.

Author information

1
Department of Urology, Medicine and Statistics, University of Washington, Seattle, USA.

Abstract

PURPOSE:

We attempt to increase our understanding of human immunodeficiency virus (HIV) shedding in semen.

MATERIALS AND METHODS:

We followed 16 seropositive men for up to 27 months by HIV cocultivation, with a subset evaluated using the polymerase chain reaction.

RESULTS:

The proportion with at least 1 HIV positive semen culture increased from 3 of 16 subjects (19%) at visit 1 to 10 (63%) by visit 5. Overall, HIV was cultured from 25 of 114 specimens (22%). Shedding was intermittent for each of the 10 men with at least 1 positive culture and seminal shedding patterns were highly variable.

CONCLUSIONS:

By culture and polymerase chain reaction, HIV is shed intermittently in the semen. If cultures are performed often enough most seropositive men shed HIV in the semen.

PMID:
7637049
[Indexed for MEDLINE]

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