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Nat Struct Biol. 1994 Sep;1(9):591-6.

Structure of a pertussis toxin-sugar complex as a model for receptor binding.

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Department of Medical Microbiology and Infectious Diseases, University of Alberta, Edmonton, Canada.


Pertussis toxin is an exotoxin from the bacterium Bordetella pertussis which is important the pathogenesis of whooping cough and the generation of a protective immune response. The diverse biological activities of the toxin depend on its ability to recognize carbohydrate-containing receptors on a wide variety of eukaryotic cells. We present here the crystal structure of pertussis toxin complexed with a soluble oligosaccharide from transferrin. Binding sites for the terminal sialic acid-galactose moiety are revealed on both subunits S2 and S3 of the B-oligomer. Identification of amino acid residues involved in receptor binding will improve the design of genetically inactivated toxins for use in new acellular whooping cough vaccines.

[Indexed for MEDLINE]

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