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Lancet. 1995 Jul 29;346(8970):281-2.

Association between clozapine response and allelic variation in 5-HT2A receptor gene.

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1
Section of Molecular Genetics, Institute of Psychiatry, London, UK.

Abstract

We report allelic association between a polymorphism (T102C) within the coding region of the 5-HT2A gene (HTR2A, 13q14-21) and response to clozapine in schizophrenic patients. Homozygosity for the C102 allele was more frequent (30/57, 53%) among patients who did not respond to clozapine than in those who responded (23/92, 25%). This finding is evidence that allelic variation of genes which encode neurotransmitter receptors can influence clinical response to antipsychotic drugs.

PMID:
7630250
[Indexed for MEDLINE]
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