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Cancer Genet Cytogenet. 1995 Jul 1;82(1):62-6.

Chromosome 12 abnormalities in malignant ovarian germ cell tumors.

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Department of Pathology, Memorial Sloan-Kettering Cancer Center, New York, NY 10021, USA.


We analyzed 3 cases of malignant ovarian germ cell tumors (MOGCTs), comprising 1 dysgerminoma and 2 immature teratomas, by banded chromosome analysis and by in situ hybridization (ISH) using a chromosome 12p painting probe. We found evidence of 12p abnormalities in two of them. A possible common genetic pathway of origin of a subset of MOGCTs with testicular germ cell tumors (TGCTs) is discussed.

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