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Am J Psychiatry. 1995 Aug;152(8):1145-9.

An MRI study of brain size in autism.

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  • 1Department of Psychiatry, University of Iowa College of Medicine, USA.

Abstract

OBJECTIVE:

This study was undertaken to obtain detailed measurements of the volume of the brain, using magnetic resonance imaging (MRI), in a carefully selected group of autistic subjects and comparison subjects.

METHOD:

Twenty-two male autistic subjects and 20 male volunteer comparison subjects were examined with detailed (1.5-mm slices) MRI throughout the entire brain. Total brain, total brain tissue, and total lateral ventricle volumes were measured by using manual tracing and automated techniques.

RESULTS:

After height and performance IQ were controlled, autistic subjects had significantly greater total brain, total tissue, and total lateral ventricle volumes than comparison subjects.

CONCLUSIONS:

These findings suggest that male autistic subjects have enlarged brains and that enlargement is a result of both greater brain tissue volume and greater lateral ventricle volume.

PMID:
7625461
DOI:
10.1176/ajp.152.8.1145
[PubMed - indexed for MEDLINE]
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