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Physiol Rev. 1995 Jul;75(3):519-60.

Flow-mediated endothelial mechanotransduction.

Author information

1
Department of Pathology, Pritzker School of Medicine, University of Chicago, Illinois, USA.

Abstract

Mechanical forces associated with blood flow play important roles in the acute control of vascular tone, the regulation of arterial structure and remodeling, and the localization of atherosclerotic lesions. Major regulation of the blood vessel responses occurs by the action of hemodynamic shear stresses on the endothelium. The transmission of hemodynamic forces throughout the endothelium and the mechanotransduction mechanisms that lead to biophysical, biochemical, and gene regulatory responses of endothelial cells to hemodynamic shear stresses are reviewed.

PMID:
7624393
PMCID:
PMC3053532
DOI:
10.1152/physrev.1995.75.3.519
[Indexed for MEDLINE]
Free PMC Article

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