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Neuropharmacology. 1995 Jan;34(1):1-26.

The metabotropic glutamate receptors: structure and functions.

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UPR-CNRS 9023, Centre CNRS-INSERM de Pharmacologie-Endocrinologie, Montpellier, France.


Glutamate is the main excitatory neurotransmitter in the brain. For many years it has been considered to act only on ligand-gated receptor channels--termed NMDA, AMPA and kainate receptors--involved in the fast excitatory synaptic transmission. Recently, glutamate has been shown to regulate ion channels and enzymes producing second messengers via specific receptors coupled to G-proteins. The existence of these receptors, called metabotropic glutamate receptors, is changing our views on the functioning of fast excitatory synapses.

[Indexed for MEDLINE]

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