Abstract
Guided by ichthyotoxic activity against goldfish, a new lipopeptide, malyngamide H [1], and its corresponding free acid, 7-methoxytetradec-4(E)-enoic acid [2], have been isolated from the tropical marine cyanobacterium Lyngbya majuscula. The structure of the new carbon skeleton borne by malyngamide H was elucidated on the basis of spectroscopic analysis, mainly 2D nmr. The absolute stereochemistry of the cyclohexenone moiety of malyngamide H [1] was deduced by a combination of 2D NOESY and exciton chirality circular dichroism spectroscopy.
Publication types
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Research Support, U.S. Gov't, P.H.S.
MeSH terms
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Animals
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Chromatography, Ion Exchange
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Circular Dichroism
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Cyanobacteria / chemistry*
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Cyclohexanones / chemistry*
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Cyclohexanones / isolation & purification
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Cyclohexanones / toxicity
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Fatty Acids, Monounsaturated / chemistry*
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Fatty Acids, Monounsaturated / isolation & purification
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Fatty Acids, Monounsaturated / toxicity
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Goldfish
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Magnetic Resonance Spectroscopy
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Stereoisomerism
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Toxins, Biological / chemistry*
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Toxins, Biological / isolation & purification
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Toxins, Biological / toxicity
Substances
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Cyclohexanones
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Fatty Acids, Monounsaturated
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Toxins, Biological
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malyngamide H