Format

Send to

Choose Destination
J Immunol Methods. 1995 Jul 17;184(1):139-43.

Monoclonal antibody mediated capsular reactions (Quellung) in Cryptococcus neoformans.

Author information

1
Department of Medicine of the Albert Einstein College of Medicine, Bronx, NY 10461, USA.

Abstract

Capsular reactions ('Quellung') visible by light microscopy were observed when capsule-binding monoclonal antibody (mAb) was added to Cryptococcus neoformans yeast cells. Capsular reactions were observed with capsule-binding IgM, IgG1, IgG2a, IgG2b, IgG3 and IgA mAbs. Scanning electron microscopy revealed that mAb binding produced a structural change in the fibrillar network of the capsule. The occurrence of capsular reactions with mAbs indicate that this phenomenon can be produced by the binding of antibody to a single epitope.

PMID:
7622865
DOI:
10.1016/0022-1759(95)00097-t
[Indexed for MEDLINE]

Supplemental Content

Full text links

Icon for Elsevier Science
Loading ...
Support Center