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J Comput Assist Tomogr. 1995 Jul-Aug;19(4):635-8.

MRI of the brain in Wilson disease: T2 signal loss under therapy.

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Institute of Diagnostic Radiology, Heinrich-Heine University of Düsseldorf, Germany.


Repeat examinations in a de novo patient with Wilson disease revealed an expansion of decreased signal intensities in the basal ganglia on T2-weighted imaging after initiation of copper trapping therapy. Since marked clinical improvement was associated with continued urinary copper excretion, iron depositioning in exchange for copper might explain these findings.

[Indexed for MEDLINE]

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