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Radiology. 1995 Aug;196(2):517-20.

Hyperacute thermal lesions: MR imaging evaluation of development in the brain.

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Department of Radiological Sciences, University of California Los Angeles School of Medicine 90024-1721, USA.



To determine the natural time course of development of hyperacute thermal lesions in the brain.


Ten interstitial lesions were created in five rabbit brains with a radio-frequency probe; an electrode-tip temperature of 80 degrees C was maintained for 60 seconds. Continuous fast spin-echo magnetic resonance (MR) imaging was used to follow lesion development for a minimum of 30 minutes. Temporal variations in lesion size and signal intensity were examined. Findings in final images were correlated with histologic findings.


Images demonstrated a focal hyperintense zone, which developed into an expanding ring of edema surrounding a necrotic center in about 10 minutes. Quantitative analysis revealed a 23% +/- 6 (standard deviation) increase in average signal intensity of the edema layer and a 152% +/- 41 increase in overall lesion size.


Full development of a thermal lesion is delayed for a period of minutes. Clinical implications of this effect should be considered when MR imaging-guided thermal ablation is performed.

[Indexed for MEDLINE]

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