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Mol Gen Genet. 1995 Jun 25;247(6):764-7.

Influence of DNA topology on expression of the tdc operon in Escherichia coli K-12.

Author information

1
Department of Biological Chemistry, The University of Michigan, Ann Arbor 48109-0606, USA.

Abstract

TdcB activity expressed from the chromosomal gene and LacZ expression from single-copy tdc-lacZ transcriptional and translational fusions were measured in Escherichia coli strains harboring mutations in the genes encoding DNA gyrase, topoisomerase I and the HU protein. The pattern of tdc operon expression in these mutants suggests that relaxation of supercoiled DNA enhances tdc transcription in vivo.

PMID:
7616969
DOI:
10.1007/bf00290409
[Indexed for MEDLINE]
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