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FEBS Lett. 1995 Jul 10;368(1):173-6.

hCAP-18, a cathelin/pro-bactenecin-like protein of human neutrophil specific granules.

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  • 1Department of Hematology, National University Hospital, Copenhagen, Denmark.


A 19 kDa protein was identified in specific granules of human neutrophils. A full-length cDNA clone was isolated from a human CML cDNA library, based on amino-acid sequences of isolated tryptic fragments. This clone includes the recently identified cDNA for FALL-39/CAP-18. Aminoacid sequences of proteolytic fragments derived both from the conserved N-terminal cathelin-like region and the highly variable C-terminal region characteristic of this family of bactericidal, LPS binding proteins, were in complete agreement with the sequence deduced from the cDNA. Thus, the 19 kDa protein is hCAP-18, stored as a 'pro-peptide' in specific granules.

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