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Trends Microbiol. 1995 Apr;3(4):149-54.

Bacterial translocation from the gastrointestinal tract.

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Dept of Microbiology and Immunology, Louisiana State University Medical School, Louisiana State University Medical Center-Shreveport 71130, USA.


Bacterial translocation is defined as the passage of viable indigenous bacteria from the gastrointestinal tract to extraintestinal sites, such as the mesenteric-lymph-node complex, liver, spleen and bloodstream. Three major mechanisms promote bacterial translocation: intestinal bacterial overgrowth, deficiencies in host immune defenses and increased permeability or damage to the intestinal mucosal barrier.

[Indexed for MEDLINE]

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