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Curr Opin Genet Dev. 1995 Apr;5(2):204-9.

The RNA polymerase II carboxy-terminal domain: links to a bigger and better 'holoenzyme'?

Author information

1
Banting and Best Department of Medical Research, University of Toronto, Ontario, Canada.

Abstract

The largest subunit of eukaryotic RNA polymerase II has an unusual tandemly repeated heptapeptide sequence at its carboxyl terminus. The function of this evolutionarily conserved carboxy-terminal domain is unknown; however, new evidence links it to the formation of a large multi-component RNA polymerase II complex possessing enhanced transcriptional initiation properties. The existence of a pre-assembled RNA polymerase II 'holoenzyme' in the cell calls into question the long held view of transcription initiation as an ordered multi-step process.

PMID:
7613090
DOI:
10.1016/0959-437x(95)80009-3
[Indexed for MEDLINE]

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