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Curr Opin Genet Dev. 1995 Apr;5(2):197-203.

The Escherichia coli RNA polymerase alpha subunit: structure and function.

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1
Department of Chemistry, Rutgers University, New Brunswick, New Jersey 08855, USA.

Abstract

Recent work has established that the Escherichia coli RNA polymerase alpha subunit consists of an amino-terminal domain containing determinants for interaction with the remainder of RNA polymerase, a carboxy-terminal domain containing determinants for interaction with DNA and interaction with transcriptional activator proteins, and a 13-36 amino acid unstructured and/or flexible linker. These findings suggest a simple, integrated model for the mechanism of involvement of alpha in promoter recognition and transcriptional activation.

PMID:
7613089
[Indexed for MEDLINE]

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