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Curr Opin Genet Dev. 1995 Apr;5(2):168-73.

Chromatin-mediated transcriptional repression in yeast.

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1
Department of Biochemistry and Molecular Biology, University of Texas, MD Anderson Cancer Center, Houston 77005, USA.

Abstract

Chromatin is linked to two modes of transcriptional repression in yeast: silencing at the HM loci and telomeres, and repression by the global regulator complex Ssn6/Tup1. In both cases, unique chromatin configurations appear to be orchestrated by multiprotein complexes targeted to particular regions through interactions with specific DNA-binding proteins, such as RAP1, the origin-recognition complex, and alpha 2.

PMID:
7613085
[Indexed for MEDLINE]
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