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Am J Ophthalmol. 1995 Jul;120(1):41-6.

Decreased basal tear turnover in patients with untreated primary open-angle glaucoma.

Author information

1
Department of Ophthalmology, Leiden University Hospital, The Netherlands.

Abstract

PURPOSE:

To detect whether untreated primary open-angle glaucoma or ocular hypertension is associated with an impaired basal tear turnover.

METHODS:

Basal tear turnover was determined by fluorophotometry in 18 patients with newly detected, untreated primary open-angle glaucoma and 29 patients with untreated ocular hypertension. The results were compared with those of 27 age-matched control subjects.

RESULTS:

The basal tear turnover in glaucoma patients (mean +/- S.D., 11.4 +/- 3.1%/min) was 22% lower than in patients with ocular hypertension (14.7 +/- 3.0%/min; P = .0007) and 27% lower than in control subjects (15.7 +/- 5.3%/min; P = .001). Tear turnover of patients with ocular hypertension did not differ significantly from that of control subjects (P = .4). The basal tear turnover values were found to decrease with increasing vertical or horizontal cup/disk ratios (P = .004 and P = .008, respectively).

CONCLUSIONS:

Primary open-angle glaucoma, but not ocular hypertension, was found to be associated with an impaired basal tear turnover. Dry eye complaints may originate from decreased basal tear turnover as a result of glaucoma drug therapy as well as from primary open-angle glaucoma itself.

PMID:
7611328
DOI:
10.1016/s0002-9394(14)73757-2
[Indexed for MEDLINE]

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