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Trends Biochem Sci. 1995 May;20(5):198-202.

ICE-like proteases in apoptosis.

Author information

1
Hanson Centre for Cancer Research, Adelaide, Australia.

Abstract

The discovery of structural and functional similarities between the product of the nematode cell-death gene ced-3 and mammalian interleukin-1 beta-converting enzyme (ICE) is providing important insights into the molecular mechanism of apoptosis. This article summarizes the current knowledge of ICE and its homologues, and how these may be involved in regulating apoptosis.

PMID:
7610484
DOI:
10.1016/s0968-0004(00)89007-6
[Indexed for MEDLINE]

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