Format

Send to

Choose Destination
Trends Biochem Sci. 1995 May;20(5):181-7.

The dynamic role of palmitoylation in signal transduction.

Author information

1
Division of Biochemistry and Molecular Biology, University of Glasgow, UK.

Abstract

Guanine nucleotide binding protein (G protein)-linked receptors, the alpha-subunits of heterotrimeric G proteins and members of the Src family of nonreceptor tyrosine kinases are among many polypeptides that are posttranslationally modified by the addition of palmitate, a long-chain fatty acid. Attachment of palmitate to these proteins is dynamic and may be regulated by their activation. The presence of palmitate appears to play a key role in the membrane localization of either the entire polypeptide or parts of it, and may regulate the interactions of these polypeptides with other proteins.

PMID:
7610481
DOI:
10.1016/s0968-0004(00)89004-0
[Indexed for MEDLINE]

Supplemental Content

Full text links

Icon for Elsevier Science
Loading ...
Support Center