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Trends Biochem Sci. 1995 May;20(5):171-5.

Are the 'core' proteins of the mitochondrial bc1 complex evolutionary relics of a processing protease?

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Institut für Genbiologische Forschung GmbH, Berlin, Germany.


The so-called 'core' proteins of the respiratory cytochrome bc1 complex and the two subunits of the mitochondrial processing peptidase (MPP) are structurally similar but their evolutionary relationship remains a mystery. Here, we present a model suggesting that the core proteins originated from an ancient proteolytic enzyme that was integrated into the bc1 complex during early stages of endosymbiosis.

[Indexed for MEDLINE]

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