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Brain Res Mol Brain Res. 1995 May;30(1):165-8.

The cellular prion protein (PrP) selectively binds to Bcl-2 in the yeast two-hybrid system.

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1
Roche Institute of Molecular Biology, Roche Research Center, Nutley, NJ 07110, USA.

Abstract

Bcl-2 can rescue neurons from death and might, therefore, exert its action by associating with neuron-specific proteins. Using LexA-Bcl-2 as bait, we find that the cellular prion protein (PrP) interacts with Bcl-2, but not Bax, in the yeast two-hybrid system. Since the PrP gene has been implicated in neurodegenerative disorders, this preliminary observation suggests a potential pathogenic mechanism for these conditions.

PMID:
7609638
[Indexed for MEDLINE]
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