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FEMS Microbiol Lett. 1995 Jun 15;129(2-3):129-33.

Cyanopeptolin S, a sulfate-containing depsipeptide from a water bloom of Microcystis sp.

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Institut für Biologie II-Mikrobiologie, Albert-Ludwigs-Universität Freiburg, Germany.


A new sulfated, cyclic depsipeptide, called cyanopeptolin S, from Microcystis sp. was isolated from a water bloom in the Auensee/Leipzig (Germany). The depsipeptide had a relative molecular mass of 925 and contained L-arginine, L-threonine, L-isoleucine, N-methyl-L-phenylalanine, a L-glutamic acid-delta-aldehyde ring system and a sulfated D-configurated glyceric acid as a side chain. The structure was elucidated by means of two-dimensional 1H and 13C nuclear magnetic resonance spectroscopy, fast atom bombardment mass spectroscopy. Fourier transformed infrared spectroscopy and combined gas-liquid chromatography/mass spectrometry. Cyanopeptolin S inhibited trypsin with an IC50 < or = 0.2 micrograms ml-1.

[Indexed for MEDLINE]

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