Send to

Choose Destination
Neurosci Lett. 1995 Apr 7;189(1):43-6.

Awakening properties of modafinil without paradoxical sleep rebound: comparative study with amphetamine in the rat.

Author information

Department of Experimental Medicine, Claude Bernard University, Lyon, France.


We have studied the effect of modafinil and amphetamine, two waking drugs, on the sleep-wake cycle of Sprague-Dawley rat. Both modafinil (64 or 128 mg/kg) and amphetamine (2.5 or 5 mg/kg) cause a dose dependent increase in wakefulness. However, amphetamine wakefulness is followed by a paradoxical sleep rebound on the injection day, whereas modafinil does not produce this effect. In modafinil-treated rats, the sleep pattern on the post-injection day is similar to that of controls, while that of amphetamine-treated rats is modified.

[Indexed for MEDLINE]

Supplemental Content

Full text links

Icon for Elsevier Science
Loading ...
Support Center