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Curr Opin Nephrol Hypertens. 1995 Mar;4(2):130-8.

Renal involvement in hematological disorders: monoclonal immunoglobulins and nephropathy.

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Department of Nephrology, Tenon Hospital, Paris, France.


The study of monoclonal immunoglobulin-associated nephropathies is useful for analyzing the physicochemical properties of immunoglobulin components responsible for their deposition in the kidney. Notable advances include the first description of truncated heavy-chain deposition disease, characterization of protease resistance and binding properties of immunoglobulin light chains involved in myeloma-associated Fanconi's syndrome and cast nephropathy, and identification of hepatitis C virus as a plausible causative agent of the so-called essential mixed cryoglobulinemias.

[Indexed for MEDLINE]

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