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Virchows Arch. 1995;426(4):385-91.

In vitro differentiation and proliferation in a newly established human rhabdomyosarcoma cell line.

Author information

1
Department of Pathology, Niigata University School of Medicine, Japan.

Abstract

A newly established cell line, designated NRS-1, was derived from an alveolar rhabdomyosarcoma that developed in the left forearm of a 7-year-old girl. The cell line had a t(2; 13) chromosomal translocation. Reverse transcription-polymerase chain reaction demonstrated that 5' PAX3-3' FKHR chimeric transcript was expressed in NRS-1 cells. NRS-1 cells showed myogenic differentiation without any particular stimulus in vitro and exhibited various kinds of muscle markers. All-trans retinoic acid promoted cell differentiation in the myogenic direction. Transforming growth factor-beta (TGF-beta) inhibited myogenic differentiation of those cells and promoted cell proliferation.

PMID:
7599791
DOI:
10.1007/bf00191348
[Indexed for MEDLINE]

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