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Dermatology. 1995;190(3):192-6.

Protection against chemotherapy-induced alopecia by cyclosporin A in the newborn rat animal model.

Author information

1
Bone Marrow Transplant Program, Duke University Medical Center, Durham, N.C., USA.

Abstract

BACKGROUND:

We have previously shown that several agents will protect against chemotherapy-induced alopecia in the newborn rat animal model. Such protective agents render the hair follicle keratinocytes resistant to chemotherapy possibly by the expression of P-glycoprotein (Pgp). Cyclosporin A (CSA) is a potent inhibitor of Pgp.

METHODS AND RESULTS:

Efficacy of CSA was tested in its effects on chemotherapy-induced alopecia in the newborn rat animal model. CSA, when applied topically, protected rats from local alopecia induced by various agents.

CONCLUSION:

The mechanism of protection by CSA and its relationship to Pgp remain uncertain. The potential clinical applicability of this observation remains to be determined.

PMID:
7599379
DOI:
10.1159/000246683
[Indexed for MEDLINE]

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