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Zhongguo Yao Li Xue Bao. 1995 Mar;16(2):172-4.

[Influence of the 2nd and 3rd grade abstracts from scorpion venom of Buthus martensii Karsch on action potentials of fast response myocardiocytes].

[Article in Chinese]

Author information

1
Central Laboratory of Physiology, Norman Bethune University of Medical Sciences, Changchun, China.

Abstract

AIM:

To screen the active components of sodium channel blockade action from Buthus martensii Karsch (BMK) scorpion venom.

METHODS:

Myocardiocytes of mice were cultured. Action potentials of fast response myocardiocytes were recorded. The effects of 22 contents of BMK scorpion venom in a concentration of 3 mg.L-1 were tested and compared with that of TTX 2.5 mg.L-1, nimodipine (Nim) 3 mg.L-1 and BaCl2 24.4 mg.L-1.

RESULTS:

BMK-1 and other 19 contents significantly decreased depolarization parameters Vmax, APA, OS, and MDP, which was similar to that of TTX and different from that of Nim and BaCl2.

CONCLUSION:

The variations in the action potentials of fast response myocardiolcytes indicated that 20 contents of BMK scorpion venom had sodium channel blockade action.

PMID:
7597923
[Indexed for MEDLINE]
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